Adaptive Trials

Adaptive Trials White Papers

Our ICON Insights will help you understand and successfully address the complexities of adaptive trial design and execution.

Use of adaptive design has rapidly risen as sponsors capitalise on its ability to increase portfolio valuation by protecting good drugs from failure and improved decision-making at critical junctures in the development process. ICON offers design, simulation and execution of adaptive clinical trials.

  • More than fifteen years of experience in successfully planning and managing over 250 adaptive clinical trials for over 30 sponsors globally
  • Experts with direct involvement in regulatory agency adoption of adaptive design trials and subsequent agency guidance
  • Operational teams and technologies to apply the power of adaptive techniques to drug and medical device trials - ICON is the only CRO to offer a validated design, simulation and analysis software platform for adaptive clinical trials. This platform, ADDPLAN, is used by regulatory agencies around the world: FDA (US), EMA (Europe) and PMDA (Japan).

Additionally, you have access to the ICON Adaptive Trial Innovation Centre, a group of world leading experts in adaptive design and execution, providing leadership in these key areas:

  • Design, simulation and execution of adaptive trials across all phases of development
  • Development of innovative trial methodologies
  • Customized training in adaptive trial statistical methodology
  • Advice and guidance on the logistical and operational requirements for successful adaptive trial execution
Reduced Mean Training Costs
Screening Rates